Projects Reports 2003

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Characteristics of antral follicles and the ability of in vitro ova maturation
Leader:  Prof. Dr. Veljko Vlaisavljević
Participants: Prof. Dr. Damjan Zazula; Boris Cigale, MSc; Jurij Munda
Project partners: Teaching Hospital of Maribor
Financed by: Ministry of Education, Science and Sport of the Republic of Slovenia
This project continues the research work done so far on the growth of dominant follicles either in natural or in stimulated cycles. Comparative examinations are gong to be conducted by a 3D ultrasound device. Therefore, the first project months were devoted to the studying of the device and its proprietary formats of the stored data. We are developing a software interface which is going to support processing of the obtained ultrasound recordings by our own recognition algorithms.

SimBio - A generic environment for bio-numerical simulation
Leader:  Asst. Prof. Dr. Božidar Potočnik
Participants: Prof. Dr. Damjan Zazula; Dušan Heric; Boris Cigale, MSc; Daniel Bernad
Project partners: University of Sheffield, Teaching Hospital of Maribor
Financed by: European Union

The central objective of the ongoing SimBio project activities is the improvement of clinical and medical practices by the use of numerical simulation for bio-medical problems. Building on existing experience with particular applications, a generic simulation environment will be produced which will provide an innovative enabling technology for advanced clinical practice and health care. A key feature in the SimBio project is the possibility to use individual patient data as input to the modelling and simulation process. The SimBio generic environment will be validated and evaluated by three specific applications:

  • electromagnetic source localisation within the human brain based on electroencephalography (EEG) and magnetoencephalography (MEG) measurements at the surface of the head;

  • bio-mechanical simulations of the human head, including modelling of neurodegenerative diseases and neurosurgical interventions;

  • the design of novel replacement parts for the menisci of the human knee joint and methods for their surgical implantation.

Our laboratory is responsible to perform site independent SimBio generic environment installation and evaluation/validation of results generated in order to solve the problem of Design of novel replacement parts for the menisci of the human knee joint and methods for their surgical implantation (prosthesis design). In last year we had begun to install the SimBio generic environment. We fixed the procedure for the MR imaging material acquisition and we also developed software interfaces for their transfer into the SimBio environment. We also developed an Image Segmentation Tool (IST tool), i.e. a helping tool for manual segmentation/annotation of the MR images (not necessarily knee images). It enables that clinicians manually annotate (segment) every 2D slice of the MR sequence.

We are also responsible for a verification of the SimBio environment image segmentation results. For this purpose we start to develop an Image Verification Tool (IPVT tool). This tool will measure an accuracy of the Simbio environment image segmentation results according to several statistical measures. Currently, the IPVT tool enables 2D verification, i.e. differences between image processing results of the SimBio environment and manual annotations of clinicians are observed on every 2D MR slice.

Project's official site: http://www.simbio.de
Project's local site: http://storm.uni-mb.si/SimBio/


NEW - Neuromuscular Assesment in the Elderly Worker
Leader:  Roberto Merletti (Politecnico di Torino, Italy)
Participants: Prof. Dr. Damjan Zazula, Dr. Dean Korošec, Aleš Holobar
Project partners: 12 European institutions (10 academic, 2 industrial), involved in SEMG research
Financed by: EU 5 FW
The main objectives of the NEW (Neuromuscular assessment in the Elderly Worker) project are non-invasive assessment of the muscle properties in the elderly workers, the prevention of muscle disorders and the reduction of its consequences. Our main focus is on the extraction of information from the raw signals detected on the muscles during their contraction, specifically on decomposition of surface EMG signals.

In last year the performance of surface EMG decomposition techniques based on the higher-order statistics was tested and improved. New approaches for optimization of non-linear equations system were developed and their performance studied. We verified some important theoretical issues concerning the model of the surface EMG signals and the achievable performance of source separation algorithms. Based on the theoretical ascertainment a new decomposition method was proposed. Although following simple decomposition concepts, the method proved to offer an equivalent performance to more complex and time consuming blind source separation methods that are based on the joint diagonalization of spatial time-frequency distributions of observed signals.

Project's official site: http://www.lisin.polito.it/new/

Project's local site: http://storm.uni-mb.si/new/

AREDVIDERO - Assessment and Revision of the Virtual Delivery Room
Leader:  Prof. Dr. Damjan Zazula
Participants: Asst. Prof. Dr. Danilo Korže, Dr. Dean Korošec, Matjaž Divjak, BSc, Aleš Holobar, BSc, 
Project partners: University of Maribor (Faculty of Electrical Engineering and Computer Science), Stanford University (Division of Neonatal and Developmental Medicine, Department of Pediatrics School of Medicine)
Financed by: Lucile Packard Foundation for Children's health center for advanced pediatric education, Slovenian Ministry of Science and Technology 
AREVIDERO (Assessment and Revision of Virtual Delivery Room) project extends the work of VIDERO (Virtual Delivery Room) project whose main goal was to create a virtual environment in which a group of medical students or even doctors could perform virtual neonatal resuscitation. AREVIDERO project concentrates on validation and verification of VIDERO’s program code, improvement and extension of newborn’s life signs, and practical evaluation of the virtual training environment in educational processes of neonatal medicine.

During last year we collaborated in start-up and testing of the VIDERO system on computers of Lucille Packard Children's Hospital at the Stanford University, Palo Alto, USA. Together with their experts we also designed a program of the validation study, in which we planned to use the VIDERO system in the introductory training of medical students. Currently the program is still in the procedure of the ethic committee of the hospital. Unfortunately, the realisation of the study had to be delayed due to very intensive activities in establishing the Center for Paediatric Education (CAPE, http://news-service.stanford.edu/news/november13/cape.html), led by Dr. Halamek. However, VIDERO is now already one of the tools in the rich arsenal of technologies, which CAPE, as the first such institution in the world, is introducing in the organised simulated training of neonatologists.

On the other hand we have meanwhile, in the scope of more technical project activities, complemented and improved our knowledge and software technologies for further development of virtual reality training systems. We obtained (outside of the AREVIDERO project, in which costs of equipment and work are not eligible) a licence for Cortona SDK software, with which we plan to design and implement new versions of the 'virtual baby', based on, of course, rich experience from both VIDERO and AREVIDERO collaborations.

CoLoS - Conceptual Learning of Science(American-European project)
Leader:  Prof. Dr. Damjan Zazula
Participants: Asst. Prof. Dr. Danilo Korže, Dr. Dean Korošec, Dr. Božidar Potocnik, Matjaž Divjak, Aleš Holobar, Iztok Prelog, Jurij Munda
Project partners: 13 European universities and Hewlett-Packard Labs, Palo Alto
Financed by: This project does not have permanent financial support
The System Software Laboratory contributed to the CoLoS activities in 2002 as well. We upgraded selected teaching tools which had been developed in the previous years. Especially a lot of attention was paid to completion of the virtual delivery room documentation, which initiated submissions of a few journal papers. The laboratory members were also invited to speak about the virtual baby at the opening plenary session of Electrotechnical and Computer Science conference ERK 2002 at Porotrož, Slovenia.

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